ARTIGOS CIENTÍFICOS

1. Klack, K., Carvalho, J.F. Vitamina K: metabolismo, fontes e interação com o anticoagulante varfarina. Rev. Bras. Reumatol. vol. 46 n° 6 São Paulo, Nov 2006.


2. Consenso Brasileiro de Osteoporose 2002.


3. Yamaguchi, M., Kakuda, H., Gao, Y.H., Tsukamoto, Y. Prolonged intake of fermented soybean ( natto ) diets containing vitamin K2 (menaquinone-7) prevents bone loss in ovariectomized rats. Journal of Bone and Mineral Metabolism, Volume 18, Number 2 (2000), 71-76.


4. Kaneki, M., Hodges, S.J., Hosoi, T., et al. Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk.Nutrition, 17(4):315-21, Apr 2001.


5. Feskanich, D,, Weber, P,, Willett, W.C., Rockett, H., Booth, S.L., Colditz, G.A.Vitamin K intake and hip fractures in women: a prospective study. Am J ClinNutr, 69(1):74-9, Jan 1999.


6. New biochemical marker for bone metabolism.Measurement by radioimmunoassay of bone GLA protein in the plasma of normal subjects and patients with bone disease.J Clin Invest; 66(5): 878–883. November 1980.


7. Steven, M., Plaza, N.D., Davis, W.,Lamson, M.S. Vitamin K2 in Bone Metabolism and Osteoporosis.Alternative Medicine Review, Volume 10, Number 1, 2005.


8. Ushiroyama, T., Ikeda, A., Ueki, M. Effect of continuous combined therapy with vitamin K(2) and vitamin D(3) on bone mineral density and coagulofibrinolysis function in postmenopausal women. Maturitas; 41:211-221, 2002.


9. Soute, B.A., Schurgers, L.J., Thijssen, H.H, De Mey, J.G., C. Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. Spronk HM. J Vasc Res. 2003 Nov-Dec;40(6):531-7.


10. Braam, L.A., Dissel, P., Gijsbers, B.L., Spronk, H.M., Hamulyák, K., Soute, B.A., Debie, W., Vermeer, C.Assay for human matrix gla protein in serum: potential applications in the cardiovascular field. ArteriosclerThrombVascBiol, 20(5):1257-61,2000.


11. Iwamoto, J., Matsumoto, H., Takeda, T. Efficacy of menatetrenone (vitamin K2) against non-vertebral and hip fractures in patients with neurological diseases: meta-analysis of three randomized, controlled trials.Clin Drug Investig. 2009;29(7):471-9.


12. Iwamoto, J., Sato, Y., Takeda, T., Matsumoto, H. Bone quality and vitamin K2 in type 2 diabetes: review of preclinical and clinical studies. Nutr Rev. 2011 Mar;69(3):162-7.


13. da Silva, A.G, Lazaretti-Castro, M. Diabetes melito, tiazolidinedionas e fraturas: uma história inacabada. ArqBrasEndocrinolMetab vol.54 no.4 São Paulo June 2010.


14. Hyung Jin Choi, MD, JuyounYu, BS, HosannaChoi. Vitamin K2 Supplementation Improves Insulin Sensitivity via Osteocalcin Metabolism: A Placebo-Controlled Trial. Diabetes Care September 2011 vol. 34 no. 9 e147.


15. Beulens JW, van der A DL, Grobbee DE, Sluijs I, Spijkerman AM, van der Schouw YT.Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes.Diabetes Care. 2010 Aug;33(8):1699-705.


16. European Food Safety Authority (EFSA): EFSA Panel on Dietetic Products, Nutrition and AllergiesScientific Opinion on the substantiation of health claims related to vitamin K and maintenance of bone, blood coagulation, and function of the heart and blood vessels pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 2009; 7 (9): 1228.